Semi-Permeable
Capsules

Accelerate your multi-step molecular analysis with Semi-Permeable Capsules

Semi-permeable capsules (SPCs) are a breakthrough technology transforming microfluidics-based multi-step workflows. SPCs are composed of an aqueous core that is surrounded by a hydrogel shell. The shell functions like a size-selective membrane, enabling the free exchange of small reaction components while maintaining compartmentalization of single cells or large biomolecules. Made from a biocompatible polymer, SPCs can be frozen, thawed, centrifuged, and used with many harsh chemical solutions. Downstream reactions can be performed in a bulk-like manner on millions of SPCs in parallel for high-throughput molecular analysis.
Effortless single-cell assays
High
Throughput
Multi-Step
Workflows
Novel
Applications
Expand your capabilities with
Multi-step workflows
MICROBIAL DNA SEQUENCING
LIQUID COLONY CULTURE
Resource downloads
WHITE PAPER Multistep workflows within microcompartments Application Note High-throughput single-cell cultivation in semi-permeable capsules Application Note Microbial target amplification in semi-permeable capsules Application Note Barcoding-free multiplex single-cell amplicon-seq enabled by semi-permeable capsules and long-read sequencing Poster Barcoding-free high-throughput single-cell targeted sequencing enabled by the 1-read-1-cel paradigm Poster High-throughput single-microbe sequencing enabled by semi-permeable capsules Technical Note Sorting of semi-permeable capsules by fluorescence-activated cell sorting
Benefits
Single-Cell
Workflows
Perform multi-step
assays without losing
compartmentalization
Optimal
Conditions
Perform every reaction in
the workflow under
optimal conditions
Massive
Parallelization
Process using bulk methods
for high-throughput
single cell studies
Versatile &
Flexible
Compatible with
diverse cell types and
biochemical reactions
Seamless
Cell Culture
Easily add nutrients
and remove wastes
for optimal cell growth
Gentle
Release
Release intact nucleic
acids or live cells
under mild conditions
WATCH OUR
ON-DEMAND SPC WEBINAR
SPC Generators
Flux is a specialized SPC generation device with a user‑friendly, one‑button operation
Exclusive SPC
generation
up to 8 samples
per run
40 minute
workflow
no microfluidics
background needed
Learn More
Onyx is a complete microfluidics solution for generating SPCs and traditional droplets
SPC or droplet
generation
1 sample
per run
90 minute
workflow
supports any
microfluidic workflow
Learn More
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