Technology

Droplet Microfluidics Unlocking new possibilities in high-throughput science

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In biological research, precise liquid handling is essential. While tubes and microwell plates have long been the standard for sample analysis, the growing demand for higher throughput and efficiency has revealed the limitations of these traditional reaction vessels. This has led to the development of a more advanced liquid handling technology—droplet microfluidics.

Droplet microfluidics compartmentalizes reactions into picoliter-volume aqueous droplets, dramatically scaling up experiments to thousands of reactions per second while minimizing reagent use and retaining the key benefits of traditional methods. As a result, droplet microfluidics has become a cornerstone for modern high-throughput research.

1 Million Reactions

Tube Microwell Plate Droplets
Duration: Months Days Minutes
Volume of Reagents: Thousands of liters Tens of liters Tens of µL
Price: $$$$ $$$ $

Features

Cost-Efficiency

Small volumes significantly reduce reagent consumption

HIGH–THROUGHPUT

Millions of cells or molecules can be isolated and analyzed within hours

FLEXIBILITY

Adaptable to a wide range of assays and applications

Applications

High-Throughput Screening

Rapidly screen diverse libraries to identify variants with desired characteristics.

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Single-cell Sequencing

Isolate single cells and replicate various protocols using droplet microfluidics.

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Other Applications

Utilize droplet microfluidics for diverse high-throughput applications, from digital assays to synthetic biology.

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Custom Microfluidic Workflows

Design tailored workflows to meet your unique research needs, leveraging customizable droplet microfluidic modules

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DROPLET MICROFLUIDICS WORKFLOWS

Droplet microfluidics workflows are executed using specialized microfluidic chips with precisely engineered microchannel patterns. These patterns enable a variety of fluidic operations by controlling the flow of immiscible liquids.

The first step in a droplet microfluidics workflow is droplet generation, where an aqueous phase and an oil phase flow through intersecting channels. At these junctions, uniform micrometer-sized droplets are formed, isolating single cells or molecules, which lay the groundwork for all subsequent manipulations and analyses.

Microfluidic chips can be fabricated in different configurations to support diverse droplet manipulations, such as mixing, splitting, and merging. These chips can be combined in modular formats, akin to building blocks, to construct customized workflows tailored to specific applications. Atrandi Biosciences provides a comprehensive range of microfluidic tools (hardware and consumables) enabling seamless execution of complete droplet-based workflows for a wide array of research needs.

Technical Note: Controllable droplet generation enhances the accuracy and sensitivity of cellular and molecular assays
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Sample encapsulation
Injection
Merging
Positive hits
Negative hits
Droplet sorting
Droplet generator & manipulator
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Fluorescence–activated droplet sorting
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MICROFLUIDIC KITS

Streamline your workflow with complete microfluidic kits, including all necessary components for hassle-free experiments, carefully selected to work together for optimal performance

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CUSTOM COMPONENTS

Tailor your microfluidic workflow with custom components, designed to meet your specific needs and applications

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