- Individual microbial cells are encapsulated within water-in-oil droplets creating isolated microreactors for massively parallel assays.
- Droplet format enables efficient high-throughput screening for desired phenotypes like improved productivity, enhanced bioconversion, or stress resistance, retaining phenotype-genotype connection.
- Facilitates exploration of vast genetic diversity for the development of optimized microbial strains.
- Contributes to the development of microbial strains tailored for biotechnological applications.
- Individual cells expressing unique antibody variants are encapsulated in picoliter-sized droplets allowing for massively parallel assays.
- Fluorescence-activated droplet sorting is used for high-throughput screening and selection of cells producing antibodies with desired characteristics.
- Droplet format enables the detection of secreted antibodies without the loss of phenotype-genotype connection.
- Contributes to the development of more effective and specific biologics, particularly in fields like immunotherapy and precision medicine.
High-throughput liquid colony culture is an advanced microbiological technique designed for parallel cultivation and screening of numerous microbial colonies in liquid media.
Single-cell microbial sequencing is an advanced genomic technique that enables the parallel analysis of individual microbial cells, allowing for a comprehensive understanding of microbial diversity and heterogeneity.