Droplet microfluidics

Accelerate Your Analysis of Biological Samples With Droplet Microfluidics

Droplet microfluidics technology is based on reaction compartmentalization into aqueous droplets with picoliter to nanoliter volumes. These droplets are capable of isolating single cells or molecules for further analysis. Thousands of droplets can be generated in a single second, enabling the high-throughput analysis of biological samples. Droplet microfluidics technology is rapidly being adopted in the biological, biomedical, and biotechnical sciences and is accelerating research at the ultimate single-cell and single-molecule resolution.
Digital Analysis
Droplets can be counted and sorted based on their size, shape, or contents using advanced imaging. Monitor and analyze droplets in real-time by detecting the fluorescence of labeled target molecules and cells. This approach enables detection of rare cells and molecules not normally seen in traditional bulk analysis.
Droplet Barcoding
Labeling individual droplets with unique oligonucleotides enables high-throughput analysis of large populations of cells or molecules. This approach allows for the simultaneous analysis of tens of thousands of droplets in a single experiment, providing a comprehensive picture of biological processes or molecular interactions.
Custom Workflows
Develop novel assays and gain new insights into your biological system with droplet microfluidics. Droplet generation, manipulation and analysis can be optimized in custom workflows to increase efficiency and sensitivity while minimizing the cost and time required for experiments.
Discover why labs around the world are switching to
Microfluidics for single-cell analysis
Analyze millions of cells or molecules within hours
Small volumes significantly reduce reagent consumption
Uniform droplets ensure reliable and reproducible results
High local concentrations maximize detection efficiency
Use any reagent and perform any molecular assay
High-throughput screening accelerates data collection
Directed Evolution
Isolate individual cells or biomolecules in aqueous droplets that serve as microreactors for in vitro selection schemes. Compartmentalization of individual variants into droplets offers precise retention of the genotype-phenotype connection and substantially reduces reagent demand. Integrated droplet manipulation capabilities are useful for assays involving reagent addition steps.
Single-Cell Sequencing
Separate individual cells with high precision into aqueous droplets of picoliter to nanoliter volumes. Droplet generation occurs at a frequency of thousands of droplets per second and is intrinsically scalable, perfect for high-throughput experiments. Cell barcoding workflows are supported for simplified sample handling without the loss of cellular identity.
Antibody Discovery
Encapsulate single mAb-secreting cells along with reporter molecules into their own reaction vessels. Generate thousands of droplets per second for massive parallelization of high-throughput experiments. Compartmentalization into droplets enables the creation of controlled microenvironments for individual mAB-secreting cells.
Drug Discovery
Compartmentalize DNA-encoded libraries into microfluidic droplets, which will preserve and retain the chemotype-genotype connection. Each aqueous droplet can serve as its own reaction vessel, allowing precise control of the concentration of small molecules within. Small droplet volumes require less sample and reagents for drug screening, significantly reducing costs.
Microbial Analysis
Isolate, manipulate, and analyze individual microbial cells, revealing the genetic and metabolic diversity of microbial populations and communities. Rapid droplet generation enables high-throughput microbial analysis, reducing time and cost. Perform culture-independent analysis, including analysis of microbial communities directly from environmental samples.
Synthetic Biology
Aqueous droplets serve as excellent microreactors for the assembly of synthetic proteins, gene circuits, and synthetic cells, as well as functional materials such as hydrogel beads. Generate thousands of picoliter- to nanoliter-sized droplets per second, enabling high-throughput experiments that save time, costs, and reagents. Precise control of the chemical microenvironment allows the fine-tuning of biological processes.
A platform that makes droplet generation and manipulation effortless. ONYX platform combines pumps, microscope, high-speed camera and high-voltage power source into an easy-to-use package that is a complete solution for any lab wanting to adopt the droplet microfluidics technology.
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Accelerate Your Research In Droplet Microfluidics
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